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Inventi Impact: Pharm Analysis & Quality Assurance

Articles

  • Inventi:ppaqa/32053/20
    Analysis of Acrylamide in Dried Blood Spots of Lung Cancer Patients by Ultra High-Performance Liquid Chromatography Tandem Mass Spectrometry
    Research 2020 : July - September
    Yahdiana Harahap, Camilla Elysia, Zenshiny Starlin, Achmad Mulawarman Jayusman

    Acrylamide (AA) is a carcinogenic substance found in food, cigarette smoke and in an environment exposed to acrylamide. This\nstudy aims to analyze AA levels in dried blood spot (DBS) samples of lung cancer patients with smoking record, without smoking\nrecord, and also in the negative blank. Analysis of AA levels was determined by liquid chromatography tandem mass spectrometry\n(LC-MS/MS) and DBS extraction using protein precipitation techniques. Mass detection was done using positive electron spray\nionization (ESI) and multiple reaction monitoring (MRM) type with m/z values of 71.99 > 55.23 for acrylamide and m/z\n260.16 > 116.04 for propranolol as the internal standard. AA levels in lung cancer patients with smoking record is in the range of........................

    How to Cite this Article
    Attribution/ CC Compliant Citation: Harahap, Yahdiana, et al.\n\"Analysis of Acrylamide in Dried Blood Spots of Lung Cancer\nPatients by Ultrahigh-Performance Liquid Chromatography\nTandem Mass Spectrometry.\" International Journal of Analytical\nChemistry 2020 (2020).\nhttps://doi.org/10.1155/2020/2015264\nhttp://creativecommons.org/licenses/by/4.0/\nSome formatting elements, header, footer, logos, dates and\npagination were modified while adapting this article.
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